There are three ways to take misoprostol pills.

You can put pills inside your cheeks, under your tongue, or in your vagina.
Choose the method that feels best to you. Do this between 24-48 hours after swallowing mifepristone.
For Mouth: Put pills inside each cheek or under your tongue. Hold them there for 30 minutes while your body absorbs the medicine. It's ok to swallow your saliva. Then swallow the pills .If you feel thirsty take warm or tea
For Vagina: Put pills in your vagina. Lie down for 30 minutes as your body absorbs the medicine. Insert the pills deep inside the vagina the deepest can.
People concerned with keeping their healthcare private usually put the misoprostol pills inside their cheeks or under the tongue. When misoprostol is inserted into the vagina, there is a chance undissolved pills could be detected during a medical exam.