How do I take the misoprostol pills?

30 minutes before you take your first dose of misoprostol:
Take pain medicine to help with cramps. Ibuprofen (Advil or Motrin) works the best, but you can take a different pain medicine like acetaminophen (Tylenol) if you need to. But don’t take aspirin because it can make you bleed more.
Take medicine for nausea if you have it.
There are a few different ways to take misoprostol.
You can put the pills in your vagina (vaginal), under your tongue (sublingual), or in your mouth between your cheeks and gums (buccal).
They will slowly dissolve (break down), and your body will absorb the medicine through the skin in your vagina or mouth. Your doctor or nurse will talk you through the best way for you to take the pills given your situation.